Diagnostic value and prognostic significance of plasmatic proteasome level in patients with melanoma.
作者： Laurent Henry , Thierry Lavabre-Bertrand , Thibaut Douche , Sandrine Uttenweiler-Joseph , Pascale Fabbro-Peray
DOI: 10.1111/J.1600-0625.2010.01151.X
关键词: Cancer 、 Population 、 Internal medicine 、 Circulating Proteasome 、 Hazard ratio 、 Cancer staging 、 Oncology 、 Melanoma 、 Subgroup analysis 、 Tumor marker 、 Pathology 、 Medicine
摘要: Plasmatic proteasome (p-proteasome) also called circulating has recently been described as a tumor marker. We investigated the diagnostic and prognostic accuracies of p-proteasome levels in melanoma population classified according to American Joint Committee on Cancer staging system. Using an ELISA test, we measured 90 patients 40 controls between March 2003 2008. The subunit composition p-proteasomes was determined metastatic by proteomic analysis. mean were correlated with stages (P 4300 ng/ml) significantly increased risk progression [hazard ratio (HR) = 7.34; 95% CI 3.54-15.21, P < 0.0001] death (HR 5.92; 2.84-12.33, 0.0001). In multivariate analysis, high poorer clinical outcome subgroup analysis limited disease I, II III. Proteomic confirmed presence all immunoproteasome subunits. Taken together, these results indicate that are new marker for dissemination melanoma.
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