Synthesis of water-soluble aminosulfonamide ligands and their application in enantioselective transfer hydrogenation
作者： Christian Bubert , John Blacker , Stephen M Brown , John Crosby , Steven Fitzjohn
DOI: 10.1016/S0040-4039(01)00623-2
关键词: Ruthenium 、 Transfer hydrogenation 、 Enantioselective synthesis 、 Base (chemistry) 、 Chemistry 、 Noyori asymmetric hydrogenation 、 Water soluble 、 Catalysis 、 Sulfonic acid 、 Organic chemistry
摘要: Abstract Water-soluble analogues of Noyori's (1S,2S)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine and Knochel's (1R,2R)-N-(p-tolylsulfonyl)-1,2-diaminocyclohexane, containing an additional sulfonic acid group, have been synthesised. The ruthenium catalysed reduction aromatic ketones using enantiomerically pure catalyst derived from water soluble ligands [RuCl2(p-cymene)]2 has examined. High enantioselectivity moderate activity were observed in the 2-propanol/base system. addition is necessary to stabilise catalyst.
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