Methods and compositions for decreasing chronic pain

作者: Douglas G. Ririe , Edward S. Boyden , Kenneth Greenberg , Benjamin C. Matteo , James C. Eisenach

DOI:

关键词: Gene silencingGene transferAnesthesiaInhibitory postsynaptic potentialChronic painPharmacologyChemistry

摘要: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination inhibitory light-sensitive protein gene transfer wavelength specific illumination.

参考文章(10)
Elaine M. Tan, Yoshiaki Yamaguchi, Gregory D. Horwitz, Simon Gosgnach, Edward S. Lein, Martyn Goulding, Thomas D. Albright, Edward M. Callaway, Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor Neuron. ,vol. 51, pp. 157- 170 ,(2006) , 10.1016/J.NEURON.2006.06.018
Michael St. Pierre, Peter W. Reeh, Katharina Zimmermann, Differential effects of TRPV channel block on polymodal activation of rat cutaneous nociceptors in vitro Experimental Brain Research. ,vol. 196, pp. 31- 44 ,(2009) , 10.1007/S00221-009-1808-3
Valérie Kayser, Florent Viguier, Myrto Ioannidi, Jean-François Bernard, Alban Latrémolière, Benoît Michot, José-Miguel Vela, Helmut Buschmann, Michel Hamon, Sylvie Bourgoin, Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats – Behavioral, pharmacological and immunohistochemical investigations Neuropharmacology. ,vol. 58, pp. 474- 487 ,(2010) , 10.1016/J.NEUROPHARM.2009.09.003
Brian Y. Chow, Xue Han, Allison S. Dobry, Xiaofeng Qian, Amy S. Chuong, Mingjie Li, Michael A. Henninger, Gabriel M. Belfort, Yingxi Lin, Patrick E. Monahan, Edward S. Boyden, High-performance genetically targetable optical neural silencing by light-driven proton pumps Nature. ,vol. 463, pp. 98- 102 ,(2010) , 10.1038/NATURE08652
Emi Shoda, Junichi Kitagawa, Ikuko Suzuki, Ieko Nitta-Kubota, Makiko Miyamoto, Yoshiyuki Tsuboi, Masahiro Kondo, Yuji Masuda, Yoshiyuki Oi, Ke Ren, Koichi Iwata, Increased phosphorylation of extracellular signal-regulated kinase in trigeminal nociceptive neurons following propofol administration in rats. The Journal of Pain. ,vol. 10, pp. 573- 585 ,(2009) , 10.1016/J.JPAIN.2008.11.013
Koichi Noguchi, Yasuhiro Morita, Hiroshi Kiyama, Keiro Ono, Masaya Tohyama, A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry Molecular Brain Research. ,vol. 4, pp. 31- 35 ,(1988) , 10.1016/0169-328X(88)90015-0
Edward Boyden, Karl Deisseroth, Feng Zhang, System for Optical Stimulation of Target Cells ,(2008)
Zahra Kiasalari, Iman Salehi, Yu Zhong, Stephen B. MCmahon, Adina T. Michael-Titus, Gregory J. Michael, Identification of perineal sensory neurons activated by innocuous heat. The Journal of Comparative Neurology. ,vol. 518, pp. 137- 162 ,(2010) , 10.1002/CNE.22187
Mariacarmela Allocca, Claudio Mussolino, Maria Garcia-Hoyos, Daniela Sanges, Carolina Iodice, Marco Petrillo, Luk H. Vandenberghe, James M. Wilson, Valeria Marigo, Enrico M. Surace, Alberto Auricchio, Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors Journal of Virology. ,vol. 81, pp. 11372- 11380 ,(2007) , 10.1128/JVI.01327-07
Anni-Maija Linden, Cristina Sandu, M. Isabel Aller, Olga Y. Vekovischeva, Per H. Rosenberg, William Wisden, Esa R. Korpi, TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Activity, Impairments in Cognitive Functions, and Reduced Sensitivity to Inhalation Anesthetics Journal of Pharmacology and Experimental Therapeutics. ,vol. 323, pp. 924- 934 ,(2007) , 10.1124/JPET.107.129544