Radiation chemical studies with nitrofurazone as related to its mechanism of radiosensitization.

摘要: The reaction rate constants for ${\rm e}{}_{aq}{}^{-}$ and OH with nitrofurazone have been experimentally measured as $2.8\times 10^{10}\ M^{-1}\ {\rm s}^{-1}$ $10.6\times 10^{9}\ respectively by pulse radiolysis techniques. Electron transfer from various substrate radicals to has observed determined. From steady-state yields of "destroyed nitrofurazone", G values determined the destruction this sensitizer separate radical species. Radiation-induced binding DNA importance is discussed in relation radiosensitizing mechanisms. Of tested, those generated reactions pyrimidines were found react most efficiently nitrofurazone. These data suggest that an important part mechanism results irreversible b...