Altered Bone Remodeling in Psoriatic Disease: New Insights and Future Directions

摘要: Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, nails. The etiology of PsA not well understood but evidence supports interplay genetic, immunologic, environmental factors which promote pathological bone remodeling joint damage PsA. Localized systemic loss due to increased activity osteoclasts established based on animal models translational studies. In contrast, the mechanisms responsible for remain enigmatic although new candidate molecules pathways have been identified. Recent reports revealed novel findings related erosion pathologic formation Many associated risk contributing molecular also this review, we discuss developments field, point out unresolved questions regarding pathogenetic origins wide array phenotypes PsA, directions investigation.