A minimal representation of the self-assembly of virus capsids.
作者： J. M. Gomez Llorente , J. Hernández-Rojas , J. Bretón
DOI: 10.1039/C4SM00087K
关键词: Frustration 、 Physics 、 Icosahedral symmetry 、 Capsomere 、 Representation (mathematics) 、 Capsid 、 Virus 、 Classical mechanics
摘要: Viruses are biological nanosystems with a capsid of protein-made capsomer units that encloses and protects the genetic material responsible for their replication. Here we show how geometrical constraints capsomer–capsomer interaction in icosahedral capsids requirement low frustration fix form shortest universal truncated multipolar expansion two-body between capsomers. The structures many related virus located as single lowest energy states potential surface built from this interaction. Our minimalist representation is consistent other models known to produce controllable efficient self-assembly, unveils relevant features natural design capsids. It promises be very useful physical virology may also interest fields nanoscience nanotechnology where similar hollow convex relevant.
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