Properties of Mesenchymal Stem Cells to Consider for Cancer Cell Therapy

摘要: Ex vivo cultured mesenchymal stem cells (MSCs) are being investigated for regenerative and cell-based therapy. The observation that human MSCs possess tumor-homing properties has generated a great deal of interest in using as carriers anti-cancer biotherapeutics. However, intrinsic may significantly affect the nature developing tumors. Therefore, understanding these interactions between tumor will be essential if to used cancer In this chapter, we firstly review cell surface antigens expressed by discuss newly described method reduce risk emboli associated with infusion. Secondly, literature on identified molecular pathways governing migration, including role toll-like receptors death receptors. Thirdly, present an overview biological survival, metastasis immune responses. Finally, describe various approaches engineer order generate efficient therapies, gene modification express cytokines infection oncolytic viruses, means redirect tropism specific microenvironments.