Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease.

作者: Maria C Edman , Srikanth R Janga , Shruti Singh Kakan , Curtis T Okamoto , Daniel Freire

DOI: 10.2217/BMM-2019-0364

关键词: α synucleinParkinson's diseaseSample collectionDiseaseMedicineOcular surfaceBioinformaticsNeuronal degenerationTearsProtein composition

摘要: Tears are a known source of biomarkers for both ocular and systemic diseases with particular advantages; specifically, the noninvasiveness of sample collection and a unique and …

参考文章(88)
Igor F. Tsigelny, Yuriy Sharikov, Wolfgang Wrasidlo, Tania Gonzalez, Paula A. Desplats, Leslie Crews, Brian Spencer, Eliezer Masliah, Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. FEBS Journal. ,vol. 279, pp. 1000- 1013 ,(2012) , 10.1111/J.1742-4658.2012.08489.X
Ilene K Gipson, Pablo Argüeso, Role of mucins in the function of the corneal and conjunctival epithelia International Review of Cytology-a Survey of Cell Biology. ,vol. 231, pp. 1- 49 ,(2003) , 10.1016/S0074-7696(03)31001-0
Liancai Mu, , Jingming Chen, Stanislaw Sobotka, Themba Nyirenda, Brian Benson, Fiona Gupta, Ira Sanders, Charles H. Adler, John N. Caviness, Holly A. Shill, Marwan Sabbagh, Johan E. Samanta, Lucia I. Sue, Thomas G. Beach, Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson's Disease Patients. Dysphagia. ,vol. 30, pp. 404- 417 ,(2015) , 10.1007/S00455-015-9612-7
Lewis Kass-Iliyya, Saad Javed, David Gosal, Christopher Kobylecki, Andrew Marshall, Ioannis N. Petropoulos, Georgios Ponirakis, Mitra Tavakoli, Maryam Ferdousi, Kallol Ray Chaudhuri, Maria Jeziorska, Rayaz A. Malik, Monty A. Silverdale, Small fiber neuropathy in Parkinson's disease: A clinical, pathological and corneal confocal microscopy study Parkinsonism & Related Disorders. ,vol. 21, pp. 1454- 1460 ,(2015) , 10.1016/J.PARKRELDIS.2015.10.019
Hsiao-Chun Cheng, Christina M. Ulane, Robert E. Burke, Clinical progression in Parkinson disease and the neurobiology of axons. Annals of Neurology. ,vol. 67, pp. 715- 725 ,(2010) , 10.1002/ANA.21995
Robert A. Sack, Ann R. Beaton, Sonal Sathe, Diurnal variations in angiostatin in human tear fluid: a possible role in prevention of corneal neovascularization. Current Eye Research. ,vol. 18, pp. 186- 193 ,(1999) , 10.1076/CEYR.18.3.186.5367
Florence Chan, Irene T. Armstrong, Giovanna Pari, Richard J. Riopelle, Douglas P. Munoz, Deficits in saccadic eye-movement control in Parkinson's disease Neuropsychologia. ,vol. 43, pp. 784- 796 ,(2005) , 10.1016/J.NEUROPSYCHOLOGIA.2004.06.026
Lei Zhou, Roger W. Beuerman, Tear analysis in ocular surface diseases Progress in Retinal and Eye Research. ,vol. 31, pp. 527- 550 ,(2012) , 10.1016/J.PRETEYERES.2012.06.002