Low risk of intracranial and systemic hemorrhages in patients on dual antiplatelet treatment beyond 1 month following neuroendovascular angioplasty and/or stent placement.
作者： Ameer E. Hassan , Haralabos Zacharatos , Gabriela Vazquez , Gustavo J. Rodriguez , M. Fareed K. Suri
DOI: 10.1111/J.1552-6569.2010.00520.X
关键词: Adverse effect 、 Angioplasty 、 Stroke 、 Stent 、 Discontinuation 、 Incidence (epidemiology) 、 Clopidogrel 、 Aspirin 、 Surgery 、 Medicine
摘要: BACKGROUND Aspirin and clopidogrel treatment beyond 1 month in patients undergoing angioplasty and/or stent placement within the extra- intracranial arteries is not defined. OBJECTIVE To determine incidence of systemic bleeding events, recurrent ischemic stroke, death treated with dual antiplatelets for greater than month. METHODS We determined rates hemorrhage, or consecutive lesions, after procedures. RESULTS Dual antiplatelet was initiated 110 following endovascular a median time period 3 months (364 person-months exposure). There were two events (1 gastrointestinal), no deaths. The rate due to premature discontinuation 8.3 per 1,000 (95%, CI [2.7-25.6]). first treatment. CONCLUSION We did find an increased risk adverse procedure, supporting safety intermediate-term as adjunct intra- extracranial placement.
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