A new plasmidic cefotaximase from patients infected with Salmonella typhimurium.
作者： A. Bauernfeind , M. Holley , R. Jungwirth , P. Mangold , T. Röhnisch
DOI: 10.1007/BF01704610
关键词: Virology 、 Ampicillin 、 Biology 、 Ceftriaxone 、 Cefotaxime 、 Tazobactam 、 Sulbactam 、 Gentamicin 、 Microbiology 、 Clavulanic acid 、 Ceftazidime
摘要: Salmonella typhimurium strains resistant to most β-lactams, co-trimoxazole, tobramycin and gentamicin were isolated from patients in two hospitals Buenos Aires, Argentina, beginning August 1990. The suffering meningitis, septicaemia or enteritis. Therapy including ampicillin, ceftriaxone failed. produced a plasmidic (pMVP-4) extended broad-spectrum β-lactamase which is more active against cefotaxime than ceftazidime (Vmax for 350 times higher ceftazidime). This cefotaximase demonstrates similarity the previously described CTX-ase-M-1 fromEscherichia coli, but it distinctly different by its isoelectric point (7.9 CTX-ase-M-2 comparison with 8.9 CTX-ase-M-1) as well lower susceptibility inhibitors sulbactam, clavulanic acid, tazobactam BRL 42715. Thus, byS. Argentina appears represent new member (CTX-ase-M-2) of novel group β-lactamases designated cefotaximases.
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