Analysis of spatial patterns in histological sections of brain tissue
作者： R.A Armstrong
DOI: 10.1016/S0165-0270(96)02221-2
关键词: Neurofibrillary tangle 、 Senile plaques 、 Pathology 、 Sample (material) 、 Anatomy 、 Common spatial pattern 、 Biology 、 Spatial ecology 、 Histology 、 Brain tissue 、 Spatial distribution
摘要: A method is described which enables the spatial pattern of discrete objects in histological sections brain tissue to be determined. The can applied cell bodies, blood vessels or characteristic lesions develop patients with neurodegenerative disorders. density feature under study measured a series contiguous sample fields arranged grid transect. Data from adjacent are added together provide data for larger field sizes. plot variance/mean ratio (V/M) versus size reveals whether distributed randomly, uniformly clusters. If clustered, analysis determines clusters randomly regularly and mean In addition, if two different features determine their phase, out phase unrelated each other. To illustrate method, patterns senile plaques neurofibrillary tangles were studied Alzheimer's disease.
elsevier.com
sci-hub.se 参考文章(19)
Kalaria Rn, The blood-brain barrier and cerebral microcirculation in Alzheimer disease. Cerebrovascular and brain metabolism reviews. ,vol. 4, pp. 226- ,(1992)
E. C. Pielou, An introduction to mathematical ecology ,(1969)
Jerrold H. Zar, James E. Brower, Carl N. von Ende, Field and laboratory methods for general ecology ,(1984)
R A Armstrong, L Wood, Spatial pattern analysis of beta-amyloid (A beta) deposits in Alzheimer disease by linear regression Alzheimer Disease & Associated Disorders. ,vol. 10, pp. 40- 45 ,(1996) , 10.1097/00002093-199601010-00007
R.A. Armstrong, Is the clustering of neurofibrillary tangles in Alzheimer's patients related to the cells of origin of specific cortico-cortical projections? Neuroscience Letters. ,vol. 160, pp. 57- 60 ,(1993) , 10.1016/0304-3940(93)90916-9
A. R. Clapham, Over-Dispersion in Grassland Communities and the Use of Statistical Methods in Plant Ecology The Journal of Ecology. ,vol. 24, pp. 232- 251 ,(1936) , 10.2307/2256277
C. V. BRUCE, J. CLINTON, S. M. GENTLEMAN, G. W. ROBERTS, M. C. ROYSTON, Quantifying the pattern of β/A4 amyloid protein distribution in Alzheimer's disease by image analysis Neuropathology and Applied Neurobiology. ,vol. 18, pp. 125- 136 ,(1992) , 10.1111/J.1365-2990.1992.TB00774.X
J. C. Errington, The Effect of Regular and Random Distributions on the Analysis of Pattern The Journal of Ecology. ,vol. 61, pp. 99- ,(1973) , 10.2307/2258920
Clustering of Ipsilateral Cortico-Cortical Projection Neurons to Area 7 in the Rhesus Monkey Proceedings of The Royal Society B: Biological Sciences. ,vol. 246, pp. 1- 9 ,(1991) , 10.1098/RSPB.1991.0117