Y chromosome's roles in sex differences in disease.

摘要: In PNAS, Krementsov et al. (1) report that if you are a male mouse and catch the flu, severity of your illness may depend on type Y chromosome (ChrY) have. this study, influenza A virus was administered to consomic ChrY strains in which numerous different versions ChrY, derived from strains, were bred onto same genetic background. This method varies composition while keeping autosomes X (ChrX) constant, so any difference pathogenesis reveals functional differences encoded by ChrYs. The influences frequency γδ T cells infected lung, their production IL-17. leads confident conclusion some elements regulate inflammatory immune responses an infectious disease. Other work Teuscher laboratory, also using demonstrates effects other viral infections autoimmune diseases, including model multiple sclerosis (2, 3). These reports important part because they bear sex immunity, but have implications for more general understanding its partner, ChrX. Further will no doubt search specific affect immunity. Although ChrX contains many genes function, until recently one might been pessimistic about finding controlling traits, function. Methods useful dissecting roles autosomal less informative ChrY. For example, almost entire is single linkage unit, studies cannot localize regions traits. Sequencing has frustrated highly repetitive nature (4⇓–6). Knocking out homologous … [↵][1]1Email: arnold{at}ucla.edu. [1]: #xref-corresp-1-1