Molecular Genetics of Myelin Basic Protein in Mouse and Humans

摘要: Myelin is a multi-lamellar membrane structure which ensheathes the axon and acts to increase nerve conduction velocity without significant in axonal diameter. occurs mainly vertebrates (1), although some invertebrates have been found myelin like as well. The sheath synthesized by oligodendrocytes central nervous system (2) (CNS) Schwann cells peripheral (3) (PNS). these two cell types morphologically similar consists of series concentrically wrapped bilayers are extensions oligodendrocyte or plasma (4). During myelination, repeatedly about then compacted at both apposed cytoplasmic extracellular surfaces form intraperiod major dense lines seen electron microscopy mature (5) [see Figure 1]. Maturation myelinating deposition is, thus, accompanied number drastic morphological physiological changes also include synthesis set new proteins only (6). Although synthesize structures, they different embryological origins distinct biological properties (2, 3). This chapter concerns gene expression, thus following discussion will focus on CNS myelination.