Underperfusion Injury in Diabetic Rat Hearts: Effects of Norepinephrine and/or Insulin on Stiffness Increase and Abnormal Energy Metabolism
作者： Makie Higuchi , Kanako Miyagi , Matao Sakanashi
DOI: 10.1007/978-0-585-39844-0_38
关键词: Diabetes mellitus 、 Endocrinology 、 Inotrope 、 Ventricular pressure 、 Norepinephrine (medication) 、 Insulin 、 Glycogen 、 Reperfusion injury 、 Ex vivo 、 Internal medicine 、 Medicine
摘要: Diabetic hearts were more susceptible than nondiabetic to flow reduction and readily exhibited an increase in left ventricular diastolic stiffness isolated rat hearts. Norepinephrine during underperfusion exacerbated the injury improved reperfusion injury, particularly diabetic hearts, while positive inotropic response was decreased by progression of diabetes. The correlated closely with ATP depletion lactate accumulation subendocardium, which metabolically subepicardium. correlation curves, however, not coincidental: critical level significantly higher markedly high glycogen content probably helps delay start injury. degree depended on duration norepinephrine severity In vivo ex insulin prevented
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