Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents.
作者： Nihal Inandiklioğlu , Adem Yaşar
关键词: Insulin resistance 、 High-density lipoprotein 、 Body mass index 、 Obesity 、 Internal medicine 、 Triglyceride 、 Cholesterol 、 FTO gene 、 Endocrinology 、 Childhood obesity 、 Medicine
摘要: Several studies have shown that rs9939609 and rs1421085 in fat mass obesity-associated (FTO) gene rs17782313 rs12970134 melanocortin-4 receptor (MC4R) influence obesity. In the present study, we aimed to determine association between rs9939609, rs1421085, rs17782313, polymorphism, their relation with body index (BMI), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) lipid values obese children. We included 100 newly diagnosed children healthy The (CC/CT) (p = 0.019) (AA/AT) (p = 0.002) polymorphism regions were higher group. Additionally, found both associated high-density lipoprotein cholesterol (p = 0.011 p = 0.003) triglycerides (p = 0.01 p = 0.004) level, respectively. Further, variants FTO HDL-cholesterol levels children; however, updated a large sample size are required establish strong links genetic risk factors childhood
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