Lysosome-related Organelles as Mediators of Metal Homeostasis

作者: Crysten E. Blaby-Haas , Sabeeha S. Merchant

DOI: 10.1074/JBC.R114.592618

关键词: ArabidopsisVacuoleBiologyIntracellularSaccharomyces cerevisiaeBiochemistryCell biologyIon transporterPermeaseAcidocalcisomeAssimilation (biology)Molecular biology

摘要: Metal ion assimilation is essential for all forms of life. However, organisms must properly control the availability these nutrients within cell to avoid inactivating proteins by mismetallation. To safeguard against an imbalance between supply and demand in eukaryotes, intracellular compartments contain metal transporters that load unload metals. Although vacuoles Saccharomyces cerevisiae Arabidopsis thaliana are well established locales storage copper, zinc, iron, manganese, related emerging as important mediators homeostasis. Here we describe review their transporter complement.

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