Phosphoinositides: Lipid regulators of membrane proteins
作者： Björn H. Falkenburger , Jill B. Jensen , Eamonn J. Dickson , Byung-Chang Suh , Bertil Hille
DOI: 10.1113/JPHYSIOL.2010.192153
关键词: Protein–lipid interaction 、 Integral membrane protein 、 Peripheral membrane protein 、 Membrane transport protein 、 Membrane budding 、 Membrane protein 、 Membrane transport 、 Biology 、 FERM domain 、 Cell biology
摘要: Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their principal role is instructional: they interact with proteins. Each cellular membrane compartment uses characteristic species phosphoinositide. This signature phosphoinositide attracts specific complement functionally important, loosely attached peripheral proteins to that membrane. For example, the phosphatidylinositol 4,5-bisphosphate (PIP2) plasma phospholipase C, protein kinase involved budding and fusion, regulating actin cytoskeleton, others. also regulate activity level integral Many ion channels need plasma-membrane-specific PIP2 function. decreases when abundance this lipid falls, as for example after activation C. behaviour illustrated by suppression KCNQ K+ channel current M1 muscarinic receptors; require their activity. In summary, phosphoinositides contribute selection each
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