Variations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation
作者： W. H. KUTTEH , S. J. PRINCE , K. R. HAMMOND , C. C. KUTTEH , J. MESTECKY
DOI: 10.1046/J.1365-2249.1996.36742.X
关键词: Uterine cervix 、 Antibody 、 Subclass 、 Isotype 、 Urinary system 、 Ovulation 、 Immunoglobulin E 、 Immunology 、 Biology 、 Luteinizing hormone
摘要: The quantity and subclass distribution of IgA produced by the human uterine cervix may have a significant impact on defence against sexually transmitted diseases as well regulation fertility. Cervical mucus was obtained from 15 normal ovulating women around time ovulation. total amounts secreted (including IgA1 IgA2), IgG, IgM were determined ELISA. detected at high levels in all samples cervical mucus. When ovulation ascertained daily urinary luteinizing hormone testing, production maximal 2–3 days before Equal proportions IgA2 mucus, 80% occurred polymeric forms. increased IgA, ratios to IgA2, predominance indicate that much fluid originates local production.
sci-hub.se 参考文章(20)
Jiri Mestecky, Jerry R. Mcghee, Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Advances in Immunology. ,vol. 40, pp. 153- 245 ,(1987) , 10.1016/S0065-2776(08)60240-0
S J Prince, J Mestecky, W H Kutteh, Tissue origins of human polymeric and monomeric IgA. Journal of Immunology. ,vol. 128, pp. 990- 995 ,(1982)
William H Kutteh, Shirley J Prince, John O Phillips, Jerry G Spenney, Jiri Mestecky, None, Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile Gastroenterology. ,vol. 82, pp. 184- 193 ,(1982) , 10.1016/0016-5085(82)90003-8
C Lue, J Mestecky, A Tarkowski, Systemic immunization with pneumococcal polysaccharide vaccine induces a predominant IgA2 response of peripheral blood lymphocytes and increases of both serum and secretory anti-pneumococcal antibodies. Journal of Immunology. ,vol. 140, pp. 3793- 3800 ,(1988)
P MILLER, M SOULES, The usefulness of a urinary LH kit for ovulation prediction during menstrual cycles of normal women Obstetrics & Gynecology. ,vol. 87, pp. 13- 17 ,(1996) , 10.1016/0029-7844(95)00352-5
William H Kutteh, Jiri Mestecky, None, Secretory Immunity in the Female Reproductive Tract American Journal of Reproductive Immunology. ,vol. 31, pp. 40- 46 ,(1994) , 10.1111/J.1600-0897.1994.TB00845.X
M. B. Parr, E. L. Parr, Immunohistochemical localization of immunoglobulins A, G and M in the mouse female genital tract. Reproduction. ,vol. 74, pp. 361- 370 ,(1985) , 10.1530/JRF.0.0740361
Per Brandtzaeg, Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scandinavian Journal of Immunology. ,vol. 22, pp. 111- 146 ,(1985) , 10.1111/J.1365-3083.1985.TB01866.X
B. M. Coughlan, G. R. B. Skinner, IMMUNOGLOBULIN CONCENTRATIONS IN CERVICAL MUCUS IN PATIENTS WITH NORMAL AND ABNORMAL CERVICAL CYTOLOGY British Journal of Obstetrics and Gynaecology. ,vol. 84, pp. 129- 134 ,(1977) , 10.1111/J.1471-0528.1977.TB12539.X
Michael W. Russell, Thomas A. Brown, Jiri Radl, Joost J. Haaijman, Jiri Mestecky, Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies. Journal of Immunological Methods. ,vol. 87, pp. 87- 93 ,(1986) , 10.1016/0022-1759(86)90347-9