Carcinogenicity of Butylated Hydroxyanisole in F344 Rats

摘要: Butylated hydroxyanisole (BHA) was added at levels of 0.5 and 2.0% to the diet inbred F344 rats for 2 years. The higher dose BHA induced a significant increase in incidence papilloma squamous cell carcinoma both sexes. Both lower doses increased incidences hyperplasia forestomach, considered be associated with neoplasias. these neoplastic changes were dose-dependent. Neoplastic other organs not significantly by BHA. These results show that is carcinogenic forestomach rats.