The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling
作者： Pavithra Aravamudhan , Alan A. Goldfarb , Ajit P. Joglekar
DOI: 10.1038/NCB3179
关键词: Biology 、 Cell biology 、 Spindle checkpoint 、 Microtubule-associated protein 、 Microtubule 、 Spindle apparatus 、 Kinetochore 、 Nocodazole 、 Saccharomyces cerevisiae 、 Cell cycle checkpoint
摘要: Joglekar and colleagues show that in budding yeast, kinetochore–microtubule attachment mediates silencing of the spindle assembly checkpoint through physical separation Mps1 kinase from its substrate Spc105.
nature.com
sci-hub.se 参考文章(69)
B.J. Howell, B.F. McEwen, J.C. Canman, D.B. Hoffman, E.M. Farrar, C.L. Rieder, E.D. Salmon, Cytoplasmic dynein/dynactin drives kinetochore protein transport to the spindle poles and has a role in mitotic spindle checkpoint inactivation Journal of Cell Biology. ,vol. 155, pp. 1159- 1172 ,(2001) , 10.1083/JCB.200105093
Ivana Primorac, John R Weir, Elena Chiroli, Fridolin Gross, Ingrid Hoffmann, Suzan van Gerwen, Andrea Ciliberto, Andrea Musacchio, Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling eLife. ,vol. 2, pp. 01030- ,(2013) , 10.7554/ELIFE.01030
S. Heinrich, H. Windecker, N. Hustedt, S. Hauf, Mph1 kinetochore localization is crucial and upstream in the hierarchy of spindle assembly checkpoint protein recruitment to kinetochores Journal of Cell Science. ,vol. 125, pp. 4720- 4727 ,(2012) , 10.1242/JCS.110387
Caren Norden, Manuel Mendoza, Jeroen Dobbelaere, Chitra V. Kotwaliwale, Sue Biggins, Yves Barral, The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage Cell. ,vol. 125, pp. 85- 98 ,(2006) , 10.1016/J.CELL.2006.01.045
Dileep Varma, Srikripa Chandrasekaran, Lynsie J. R. Sundin, Karen T. Reidy, Xiaohu Wan, Dawn A. D. Chasse, Kathleen R. Nevis, Jennifer G. DeLuca, E. D. Salmon, Jeanette Gowen Cook, Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore microtubule attachment Nature Cell Biology. ,vol. 14, pp. 593- 603 ,(2012) , 10.1038/NCB2489
Foong May Yeong, Hong Hwa Lim, C.G. Padmashree, Uttam Surana, Exit from mitosis in budding yeast: biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20. Molecular Cell. ,vol. 5, pp. 501- 511 ,(2000) , 10.1016/S1097-2765(00)80444-X
Jessica S. Rosenberg, Frederick R. Cross, Hironori Funabiki, KNL1/Spc105 recruits PP1 to silence the spindle assembly checkpoint. Current Biology. ,vol. 21, pp. 942- 947 ,(2011) , 10.1016/J.CUB.2011.04.011
Kuo-Shun Hsu, Takashi Toda, Ndc80 Internal Loop Interacts with Dis1/TOG to Ensure Proper Kinetochore-Spindle Attachment in Fission Yeast Current Biology. ,vol. 21, pp. 214- 220 ,(2011) , 10.1016/J.CUB.2010.12.048
Thomas J. Maresca, Edward D. Salmon, Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity Journal of Cell Biology. ,vol. 184, pp. 373- 381 ,(2009) , 10.1083/JCB.200808130
Carlos Sacristan, Geert J.P.L. Kops, Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling Trends in Cell Biology. ,vol. 25, pp. 21- 28 ,(2015) , 10.1016/J.TCB.2014.08.006