MetaRiPPquest: A Peptidogenomics Approach for the Discovery of Ribosomally Synthesized and Post-translationally Modified Peptides
作者： Hosein Mohimani , Alexey Gurevich , Kelsey L Alexander , C Benjamin Naman , Tiago Leao
DOI: 10.1101/227504
关键词: Antibiotics 、 Genome 、 Computational biology 、 Natural product 、 Tandem mass spectrum 、 Computer science 、 Metagenomics 、 Molecular networking
摘要: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an important class of natural products that include many antibiotics a variety other bioactive compounds. While recent breakthroughs in RiPP discovery raised the challenge developing new algorithms for their analysis, peptidogenomic-based identification RiPPs by combining genome/metagenome mining with analysis tandem mass spectra remains open problem. We present here MetaRiPPquest, software tool addressing this is compatible large-scale screening platforms product discovery. After searching millions Global Natural Products Social (GNPS) molecular networking infrastructure against just six genomic metagenomic datasets, MetaRiPPquest identified 27 known discovered 5 novel products.
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