The greater atherogenicity of nonpurified diets versus semipurified diets in hamsters is mediated via differences in plasma lipoprotein cholesterol distribution, ldl oxidative susceptibility, and plasma α-tocopherol concentration

摘要: In the current study, plasma lipid, lipoprotein cholesterol and α-tocopherol concentrations, LDL oxidative susceptibility, early aortic atherosclerotic responses of feeding a hypercholesterolemic nonpurified or semipurified diet containing similar levels macro- certain micro-nutrients were compared in hamsters. Although total (TC) concentrations hamsters fed versus significantly higher (P < 0.05), non-high density (non-HDL-C) 41% greater non-purified 0.05). This non-HDL-C concentration, coupled with lower high-density (HDL-C) resulted non-HDL-C/HDL-C TC/HDL-C ratios for Despite comparable amounts dietary vitamin E, 233% Resistance to oxidation, as measured by lag phase conjugated diene formation, was reduced nearly 50%, rate formation dienes 105% diet, respectively Early atherosclerosis fivefold diet. These results suggest that, despite many micro-nutrients, ingestion diets is associated more atherogenic profile, levels, diets.