Comparison of adrenal vein sampling and computed tomography in the differentiation of primary aldosteronism.

摘要: Determination of the etiology primary aldosteronism remains a diagnostic challenge. The most common types are bilateral adrenal hyperplasia (BAH), aldosterone-producing adenomas (APA), and hyperplasia. Computed tomography (CT) vein sampling (AVS) modalities used to differentiate these subtypes. purpose this study was compare AVS CT imaging glands in patients with hyperaldosteronism whom normal or focal unilateral abnormalities were detected. diagnosis made 62 based on an elevated plasma aldosterone PRA ratio urinary excretion rate. Thirty-eight had successful included final analysis. considered gold standard determining specific subtype aldosteronism. There 15 APA, 21 BAH, 2 Plasma significantly higher APA (46.3 +/- 8.5 ng/dL; 1284 235 pmol/L) than those BAH (29.3 2.4 813 11 pmol/L; P < 0.05). potassium lower (3.1 0.1 mmol/L) (3.5 mmol/L; 0.02). considerable overlap other biochemical indices (e.g. aldosterone) different In proven by AVS, eight concordant findings imaging, four discordant findings, three imaging. nine Compared either inaccurate provided no additional information 68% We conclude that is not reliable method Adrenal essential establish correct