Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition.
作者： A Elizabeth Linder , David S Weber , Steven E Whitesall , Louis G D??Alecy , R Clinton Webb
DOI: 10.1097/01.FJC.0000175879.14994.63
关键词: Nitric oxide synthase 、 Nitric oxide 、 Vasodilation 、 Chemistry 、 Internal medicine 、 ATP synthase 、 Vascular reactivity 、 Endocrinology
摘要: Abstract:This study tested the hypothesis that nitric oxide (NO) synthase inhibition in mice would result hypertension characterized by increased agonist-induced vasoconstrictor responsiveness and attenuated endothelium-dependent vasodilation. Administration of Nω-nitro-L-arginine (L-NNA), an NO
elsevier.com
sci-hub.se 参考文章(40)
C. Nathan, Q.W. Xie, Regulation of biosynthesis of nitric oxide. Journal of Biological Chemistry. ,vol. 269, pp. 13725- 13728 ,(1994) , 10.1016/S0021-9258(17)36703-0
Roberto S. Cunha, Antonio M. Cabral, Elisardo C. Vasquez, Evidence that the Autonomic Nervous System Plays a Major Role in the L-NAME - Induced Hypertension in Conscious Rats American Journal of Hypertension. ,vol. 6, pp. 806- 809 ,(1993) , 10.1093/AJH/6.9.806
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
Veronica A. Peotta, Elisardo C. Vasquez, Silvana S. Meyrelles, Cardiovascular neural reflexes in L-NAME-induced hypertension in mice. Hypertension. ,vol. 38, pp. 555- 559 ,(2001) , 10.1161/01.HYP.38.3.555
Brett M. Mitchell, Anne M. Dorrance, Adviye Ergul, R. Clinton Webb, Sepiapterin Decreases Vasorelaxation in Nitric Oxide Synthase Inhibition–Induced Hypertension Journal of Cardiovascular Pharmacology. ,vol. 43, pp. 93- 98 ,(2004) , 10.1097/00005344-200401000-00014
YasufumiShirasaki, Che Su, Endothelium removal augments vasodilation by sodium nitroprusside and sodium nitrite. European Journal of Pharmacology. ,vol. 114, pp. 93- 96 ,(1985) , 10.1016/0014-2999(85)90527-8
Lars Rothermund, Andreas Friebe, Martin Paul, Doris Koesling, Reinhold Kreutz, Acute blood pressure effects of YC‐1‐induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats British Journal of Pharmacology. ,vol. 130, pp. 205- 208 ,(2000) , 10.1038/SJ.BJP.0703320
L J Ignarro, Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension. ,vol. 16, pp. 477- 483 ,(1990) , 10.1161/01.HYP.16.5.477
S. Moncada, D. D. Rees, R. Schulz, R. M. Palmer, Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 2166- 2170 ,(1991) , 10.1073/PNAS.88.6.2166
Roberto Zatz, Christine Baylis, Chronic Nitric Oxide Inhibition Model Six Years On Hypertension. ,vol. 32, pp. 958- 964 ,(1998) , 10.1161/01.HYP.32.6.958