Islet transplantation a review of the objective, the concepts, the problems, the progress and the future

摘要: If one examines the impact in world today that results from complications of diabetes mellitus, recognizes need to find an alternative therapy standard use exogenous insulin injections. The total this disease USA has been estimated be $ 14 billion affecting some 2 million patients with Type I, Insulin Dependent Diabetes Mellitus (IDDM), and 8–10 II, non-IDDM [1]. It is microvascular make third leading cause death, new blindness, kidney failure resulting 30% transplants done country, a major contributor myocardial infarction stroke, gangrene amputation, important male impotence. not prevented these date. New efforts monitoring treatment have certainly changed way I care for themselves. Yet, definitive proof aggresive control significantly reducing risk still available. While research into pathophysiology their prevention are imperative answer basic question, tranplantation islet tissue also development clinical trials may provide answers.