Cardiopulmonary changes induced during one-lung ventilation in anesthetized dogs with a closed thoracic cavity.

摘要: Objective—To evaluate the effects of one-lung venti- lation (OLV) on oxygen delivery (DO2) in anesthetized dogs with a closed thoracic cavity. Animals—7 clinically normal adult Walker Hound dogs. Procedure—Dogs were anesthetized. Catheters inserted dorsal pedal artery and pul- monary artery. Dogs positioned right lateral recumbency. Data collected at baseline (PaCO2 35 to 45 mm Hg), during two-lung ventilation, 15 minutes after creating OLV. Hemodynamic res- piratory variables analyzed calculations per- formed obtain DO2, values compared among various time points by use an ANOVA for repeated measures. Results—OLV induced significant augmentation shunt fraction that resulted reduction PaO2, arterial saturation, content. Cardiac index was not significantly changed. The net result DO2 affected Conclusions Clinical Relevance—Use OLV healthy does induce changes which is ultimate variable when eval- uating tissue oxygenation. One-lung ventilation can be initiated safely before entering cavity surgery. Additional studies are neces- sary patients variations age, body position, type anesthet- ic protocol. (Am J Vet Res 2005;66:973-977)