Participation of the cholinergic system in ameliorating effect of vasopressin fragment by group I metabotropic glutamate-receptor blockade.
作者： Tadatsugu Tarumi , Azusa Mikami , Kenichi Shimada , Chiaki Kamei
DOI: 10.1254/JPHS.08146FP
关键词: Chemistry 、 Mecamylamine 、 Scopolamine Hydrobromide 、 Internal medicine 、 Hippocampus 、 Antagonist 、 Metabotropic receptor 、 Anesthesia 、 Endocrinology 、 Working memory 、 Glutamate receptor 、 Muscarinic acetylcholine receptor
摘要: The effect of [pGlu4,Cyt6,Arg8]-vasopressin fragment 4-9 (AVP4-9) on group I metabotropic glutamate (mGlu1) receptor antagonist-induced memory deficits was studied using 8-arm radial maze performance with 4 arms baited. In addition, the participation cholinergic system in ameliorating AVP4-9 mGlu1 also investigated. Intrahippocampal injection (R,S)-1-aminoindan-1,5-dicarboxylic acid (AIDA), an mGlu1-receptor antagonist, significantly increased total error, reference and working error at a dose 20 nmol/side. (0.1 1.0 microg/kg, s.c.) showed significant ameliorative AIDA-induced deficits. Improvement deficit response to treatment antagonized by scopolamine (5 nmol/side) but not mecamylamine (200 that caused no when injected separately. These findings indicate may be closely associated muscarinic receptor.
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