VARIABILITE INTERINDIVIDUELLE PHARMACOCINETIQUE ET PHARMACODYNAMIQUE EN ONCOLOGIE : APPLICATION AU DOCETAXEL ET A LA VINORELBINE
作者： Florent Puisset
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摘要: Pour optimiser l'utilisation des cytotoxiques, leurs doses doivent etre adaptees en fonction capacites individuelle d'elimination, et de la sensibilite propre chaque patient vis a cytotoxiques. Nos travaux avaient pour objectif predire l'elimination deux substrats du cytochrome P4503A (docetaxel vinorelbine) grâce dexamethasone, rechercher les facteurs au docetaxel. Par une approche pharmacocinetique population (NONMEM) nous avons pu mettre evidence relation entre clairance (CL) dexamethasone CL docetaxel comme avec vinorelbine. Un modele pharmacocinetique-pharmacodynamique semi-physiologiue ete utilise decrire neutropenie induite par le docetaxel, permettant quantifier variabilite inter-individuelle pharmacodynamique d'etudier influents cette variabilite.
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