The Mechanism of the Persistent Light Reactor**From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

摘要: Jilison and Eaughman (1) coined the term "persistent light reactor" to describe patients with photoallergic contact dermatitis bithionol who remained abnormally susceptible sunlight for months or even years after terminating all known photosensitizer. These exhibited an increased susceptibility erythemic radiation indicated by low minimum erythema doses (MED's). Moreover, phototests through window glass produced redness. Observations of persistent reactors have also been made Wilkinson in England (2), Sidi France (3), Wiskemann WuIf Germany (4). Although photoallergens included a variety chemicals such as chlorpromazine (4) promethazine sulfanilamide (5), blankophores (6), tars (7), typical cause is use soaps topical preparations containing halogenated salicylanilides related compounds bacteriostats, viz., 3,3',4',5 tetrachlorosalicylanilide (TCSA), 3 ,4',5 tribromosalicylanilide (TES), 4',S dibromosalicylanilide (DES), 3,4,4' trichlorocarbanilide (TCC), 4,4' dichloro trifluoromethylcarbanilide (TFC), bithionol, hexachlorophene. The reactor presents wretched picture his intensely pruritic, ec2ematized, lichenified, chronic dermatitis. He becomes inhabitant shadows, being so sensitive that indirect has be scrupulously avoided. puzzling feature sustained photosensitivity long last exposure chemical. paradox called forth hypotheses as: 1) autologous part photoallergenic molecule,