Effect of lipolytic agents on healthy and pathological human adipose tissue.

摘要: Summary Lipolytic process in lipomata offers a new approach to elucidate the control mechanism of hormonal action human adipose tissue. The aim present work has been establish, first, if lipolytic drugs affected differently normal from pathological Second, it was interest pathology included any change lipolysis which could result altered lipomobilization. Three types lipomatosis were examined and compared with subcutaneous tissue (NT) same patients. Pathological obtained patients multiple symmetric (MSL), Barraquer Simmons (BS) simple, or nodular, (SL). studied a) by determination FFA content, glycerol release into incubation medium either under basal conditions after addition adipokinetic agents such as catecholamines, theophylline dibutyryl cyclic AMP (db-cAMP). b) Basal intraccllular ATP content quantified both tissues. rate closely similar between simple lipomatosis. On contrary, response lipomobilizing distinctly MSL BS In lipomatous only db-cAMP stimulated markedly, whereas catecholamine induced absent. this however cholera toxin an high dose-dependent effect. lipoma neither nor found. These results suggest fine modulation man biochemical events within point distinct modalities