Comparison of the intestinal absorption and bioavailability of γ-tocotrienol and α-tocopherol: in vitro, in situ and in vivo studies
作者： Bilal S. Abuasal , Hisham Qosa , Paul W. Sylvester , Amal Kaddoumi
DOI: 10.1002/BDD.1790
关键词: Intestinal permeability 、 Oral administration 、 Tocotrienol 、 In vivo 、 Intestinal absorption 、 Corn oil 、 Pharmacology 、 Chemistry 、 Bioavailability 、 Permeability (electromagnetism) 、 Pharmacology (medical) 、 Pharmaceutical Science 、 General Medicine
摘要: … One gram of the tested formulation (10 mg/ml of γ-T3 or α-Tph dissolved in vitamin E stripped corn oil that corresponded to concentrations of 23 and 24 µ m for γ-T3 and α-Tph, …
sci-hub.se 参考文章(39)
Dimitrios G Fatouros, Anette Mullertz, In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability. Expert Opinion on Drug Metabolism & Toxicology. ,vol. 4, pp. 65- 76 ,(2008) , 10.1517/17425255.4.1.65
Laurence Barthe, John Woodley, Georges Houin, Gastrointestinal absorption of drugs: methods and studies Fundamental & Clinical Pharmacology. ,vol. 13, pp. 154- 168 ,(1999) , 10.1111/J.1472-8206.1999.TB00334.X
Bilal Abuasal, Paul W. Sylvester, Amal Kaddoumi, Intestinal Absorption of γ-Tocotrienol Is Mediated by Niemann-Pick C1-Like 1: In Situ Rat Intestinal Perfusion Studies Drug Metabolism and Disposition. ,vol. 38, pp. 939- 945 ,(2010) , 10.1124/DMD.109.031567
Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah, John R. Crison, A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Pharmaceutical Research. ,vol. 12, pp. 413- 420 ,(1995) , 10.1023/A:1016212804288
David G. Cornwell, Jiyan Ma, Studies in vitamin E: biochemistry and molecular biology of tocopherol quinones. Vitamins and Hormones Series. ,vol. 76, pp. 99- 134 ,(2007) , 10.1016/S0083-6729(07)76005-3
Örjan Carlborg, Ulrika S. H. Svensson, Michael Ashton, Hans Lennernäs, Rikard Sandström, High in situ rat intestinal permeability of artemisinin unaffected by multiple dosing and with no evidence of P-glycoprotein involvement Drug Metabolism and Disposition. ,vol. 27, pp. 227- 232 ,(1999)
A A Qureshi, N Qureshi, J J K Wright, Z Shen, G Kramer, A Gapor, Y H Chong, G DeWitt, A S H Ong, D M Peterson, B A Bradlow, Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee) The American Journal of Clinical Nutrition. ,vol. 53, ,(1991) , 10.1093/AJCN/53.4.1021S
Daniel Hollander, Elena Rim, K.S. Muralidhara, Mechanism and Site of Small Intestinal Absorption of α-Tocopherol in the Rat Gastroenterology. ,vol. 68, pp. 1492- 1499 ,(1975) , 10.1016/S0016-5085(75)80137-5
Harry R Davis, Enrico P Veltri, Zetia : Inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to Reduce Intestinal Cholesterol Absorption and Treat Hyperlipidemia Journal of Atherosclerosis and Thrombosis. ,vol. 14, pp. 99- 108 ,(2007) , 10.5551/JAT.14.99
Hazem Ali, Mahmoud Nazzal, Abdel-Azim A. Zaghloul, Sami Nazzal, Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of α-tocopherol self-emulsified drug delivery systems (SEDDS) International Journal of Pharmaceutics. ,vol. 352, pp. 104- 114 ,(2008) , 10.1016/J.IJPHARM.2007.10.023