Why are most mutations recessive

摘要: It is a long-standing observation that most mutations are recessive. That is, they do not lead to visible phenotypic effects when in heterozygous combination with the wild-type allele. The reason for this has long been debated. Fisher (1930) attributed observed dominance of wild type action natural selection at modifier loci. Wright (1929) on other hand asserted did have selective functionper se, but was more-or-less automatic offshoot genetic regulatory mechanisms. present essay discusses these explanations from contemporary standpoint and suggests neither likely be valid exclusively. In particular, even physiology appears offer sufficient explanation, evolution cannot ruled out.