CRTH2 expression on T cells in asthma
作者： K. Mutalithas , C. Guillen , C. Day , C. E. Brightling , I. D. Pavord
DOI: 10.1111/J.1365-2249.2010.04161.X
关键词: Internal medicine 、 T cell 、 Interferon 、 Interleukin 、 Medicine 、 Interleukin 13 、 Endocrinology 、 Bronchoalveolar lavage 、 Interleukin 4 、 Prostaglandin D2 、 Population 、 Immunology
摘要: Mast cell-derived prostaglandin D2 (PGD2) is the major prostanoid found within airway of asthmatics immediately following allergen challenge. PGD2 has been shown to have chemokinetic effects on eosinophils and T helper type 2 (Th2) cells in vitro. This occurs through interaction with G-protein-coupled chemokine receptor homologous molecule expressed Th2 lymphocytes (CRTH2). The expression CRTH2 be highly selective for cells. Using flow cytometry we studied blood bronchoalveolar lavage fluid normal subjects. was confined a small percentage (1.8%+/-0.2) (1.6%+/-0.2) enriched significantly interleukin (IL)-4+/IL-13+ compared interferon (IFN)-gamma+ (P<0.001). There population CRTH2+ (BAL) (2.3%+/-0.6) subjects (0.3%+/-0.1), there significant difference between two groups (P<0.05). were similar amounts BAL asthma Within paired blood-BAL samples from same subject no increase asthmatics. Enrichment IL-4+ IL-13+ IFN-gamma+ also seen preferentially by IL-4+/IL-13+ However, given their numbers they are unlikely involvement pathogenesis asthma. antagonism may not diminish cell accumulation asthmatic lung.
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