Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces

摘要: Estimating tibiofemoral joint contact forces is important for understanding the initiation and progression of knee osteoarthritis. However, force predictions are influenced by many factors including muscle anatomical representations joint. This study aimed to investigate influence subject-specific geometry kinematics on prediction using a calibrated EMG-driven neuromusculoskeletal model knee. One participant fitted with an instrumented total replacement walked at self-selected speed while medial lateral forces, ground reaction whole-body kinematics, lower-limb activity were simultaneously measured. The combination generic resulted in four different OpenSim models used estimate muscle-tendon lengths moment arms. geometric was created from CT scans representing translation tibia relative femur obtained fluoroscopy. one walking trial, but three cost functions that tracked flexion/extension moments without constraint over estimated forces. then predicted five other trials. use minimization peak improved accuracy 47% 7%, respectively compared musculoskeletal model.