The Aβcentric Pathway of Alzheimer’s Disease

作者: Victor L. Villemagne , Roberto Cappai , Kevin J. Barnham , Robert A. Cherny , Carlos Opazo

DOI: 10.1007/978-1-84628-440-3_2

关键词: Risk factorDown syndromeDiseaseInternal medicineOncologyCognitive declineProgressive neurodegenerative disorderDementiaAmyloid precursor proteinSenile plaquesMedicine

摘要: Alzheimer’s disease (AD), the leading cause of dementia in the elderly, is an irreversible, progressive neurodegenerative disorder clinically characterized by memory loss and cognitive …

参考文章(456)
A G Lindgren, H Sjogren, T Sjogren, Morbus Alzheimer and morbus Pick; a genetic, clinical and patho-anatomical study. Acta psychiatrica et neurologica Scandinavica. Supplementum. ,vol. 82, pp. 1- 152 ,(1952)
Craig S. Atwood, Xudong Huang, Robert D. Moir, Rudolph E. Tanzi, Ashley I. Bush, Role of free radicals and metal ions in the pathogenesis of Alzheimer's disease. Metal Ions in Biological Systems. ,vol. 36, pp. 309- 364 ,(2018) , 10.1201/9780203747605-10
S L Kuentzel, S M Ali, R A Altman, B D Greenberg, T J Raub, The Alzheimer β-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells Biochemical Journal. ,vol. 295, pp. 367- 378 ,(1993) , 10.1042/BJ2950367
R. E. Tanzi, C. Glabe, R. C. Scarpa, D. Fairlie, C. S. Atwood, J. D. Tyndall, K. C. Stokes, X. Huang, G. R. Hanson, L. E. Goldstein, R. D. Moir, M. P. Cuajungco, A. J. Saunders, A. I. Bush, E. F. Bowden, M. Leopold, J. Lim, M. A. Hartshorn, G. Multhaup, C. L. Masters, Cu (II ) Potentiation of Alzheimer Ab Neurotoxicity Jornal of Biological Chemistry. ,vol. 274, pp. 37111- 37116 ,(1999)
P F Good, A Hsu, D P Perl, P Werner, C W Olanow, Evidence of neuronal oxidative damage in Alzheimer's disease. American Journal of Pathology. ,vol. 149, pp. 21- 28 ,(1996)
Tanzi Re, Roher Ae, Scarpa Rc, Atwood Cs, Khatri A, Bush Ai, Huang X, Moir Rd, Kim Ys, Copper catalyzed oxidation of Alzheimer Abeta. Cellular and Molecular Biology. ,vol. 46, pp. 777- ,(2000)
K. S. Montine, T. J. Montine, D. G. Graham, V. Amarnath, W. O. Whetsell, S. J. Olson, Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4. American Journal of Pathology. ,vol. 150, pp. 437- 443 ,(1997)
K. A. Jellinger, C. Bancher, Neuropathology of Alzheimer's disease: a critical update. Journal of Neural Transmission-supplement. ,vol. 54, pp. 77- 95 ,(1998) , 10.1007/978-3-7091-7508-8_8
Changiz Geula, Pathological Diagnosis of Alzheimer’s Disease Humana Press, Totowa, NJ. pp. 65- 82 ,(2000) , 10.1007/978-1-59259-005-6_3