Dietary supplementation with conjugated linoleic acid does not improve nutritional status of tumor-bearing rats.

摘要: Tumor necrosis factor–α (TNF) is an immunoregulatory cytokine that plays a major role in tumor-induced anorexia and weight loss. Conjugated linoleic acids (CLA) are naturally occurring isomers of acid that, when added to the diet, improve food intake body mice injected with TNF. The purpose present study was examine effects diet supplemented 0.5% CLA on nutritional status rats implanted Morris 7777 hepatoma. Body weight, intake, serum levels insulin-like growth factor, splenocyte synthesis TNF were not different tumor-bearing animals fed versus control diet. However, insulin increased both given CLA. did nor alter hypophagic rats. biological significance remains be determined. © 2002 John Wiley & Sons, Res Nurs Health 25:49–57, 2002.