Antipsychotic efficacy: relationship to optimal D2-receptor occupancy.

摘要: Clinically important differences exist between antipsychotic agents and formulations in terms of safety tolerability. Features the biochemical interaction D2-receptor may underlie these differences. This article reviews current information on relationship receptor occupancy clinical response. A literature search was performed using keywords ‘antipsychotic or neuroleptic’, ‘receptor’ ‘occupancy’ ‘dopamine’ ‘D2’ supplemented by authors’ knowledge literature. Imaging data have generally supported hypotheses that optimal striatum lies a ‘therapeutic window’ ∼65 ∼80%, however, pharmacokinetic pharmacodynamic properties drug should also be taken into account to fully evaluate its therapeutic effects. Additional research, perhaps preclinical models, is needed establish various regions brain duration blockade order maximise efficacy tolerability profiles atypical antipsychotics thereby improve treatment outcomes for patients with schizophrenia.