Appetite-Related Gut Peptides in Obesity and Binge Eating Disorder.

摘要: The worldwide increase in obesity prevalence is a result of positive energy balance, with intake exceeding expenditure. eating behavior ranges from mild passive overconsumption to excessive overeating loss control observed binge disorder (BED). signaling systems that underlie appetite BED are complex and, at this point, not well understood. present review highlights the current knowledge key components gut peptide system and examines evidence defects differentiate obese eaters non-binge eaters. network underlying hunger, satiety, metabolic status includes leptin insulin stores cholecystokinin, glucagon-like peptide-1, YY(3-36), ghrelin gastrointestinal tract. Of many peptides, only established appetite-stimulating one, whereas YY(3-36) promote satiety. Adipose tissue provides hormonal signals via brain about likely adiponectin resistin. Binge has been related dysfunction system. Moreover, larger gastric capacity may further reduce satiety contribute overeating.