Bilayer Cylindrical Conduit Consisting of Electrospun Polycaprolactone Nanofibers and DSC Cross-Linked Sodium Alginate Hydrogel to Bridge Peripheral Nerve Gaps.
作者： Neshat Askarzadeh , Masoumeh Haghbin Nazarpak , Korosh Mansoori , Mehdi Farokhi , Mahdi Gholami
关键词: Ultimate tensile strength 、 Electrical conduit 、 Nanofiber 、 Adhesion 、 Electrospinning 、 Polycaprolactone 、 Layer (electronics) 、 Bilayer 、 Chemical engineering 、 Materials science
摘要: Herein, a bilayer cylindrical conduit (P-CA) is presented consisting of electrospun polycaprolactone (PCL) nanofibers and sodium alginate hydrogel covalently cross-linked with N,N'-disuccinimidyl carbonate (DSC). The P-CA developed by combining the electrospinning outer-inner layer methods. Using DSC, as covalent crosslinker, increases degradation time up to 2 months. swelling ratio also 503% during first 8 h. DSC in inner promotes adhesion proliferation nerve cells, while PCL outer provide maximum tensile strength surgery. migration Schwann cells along axon rat model based on functional histological evidences. In conclusion, will be promising construct for repairing sciatic nerves model.
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