Interplay between the bacterial protein deacetylase CobB and the second messenger c-di-GMP.
作者： Fanlin Wu , Lili Qian , Bingbing Hao , Daniel M Czajkowsky , Shujuan Guo
关键词: Biology 、 Acetylation 、 Transcriptional regulation 、 Second messenger system 、 Biogenesis 、 Protein deacetylation 、 Protein deacetylase 、 Chemotaxis 、 DNA supercoil 、 Cell biology
摘要: As a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis, DNA supercoiling many bacteria. Using an Escherichia coli proteome microarray, we found strongly binds to CobB. Further, deacetylation assays showed inhibits activity of thereby modulates biogenesis acetyl-CoA. Interestingly, also one enzymes directly involved production, DgcZ, substrate Deacetylation DgcZ by enhances its thus production c-di-GMP. Our work establishes novel negative feedback loop linking CobB-mediated deacetylation.
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