Normocalcemic Hyperparathyroidism and Hypoparathyroidism in Two Community-Based Nonreferral Populations

摘要: Context Normocalcemic primary hyperparathyroidism is typically identified after referral to a specialty clinic. At diagnosis, patients demonstrate features seen in hypercalcemic hyperparathyroidism. hypoparathyroidism has been discovered hypocalcemia unmasked bisphosphonate administration. Objective We hypothesized that screening unselected, nonreferral populations, such as The Osteoporotic Fractures Men (MrOS) study and Dallas Heart Study (DHS), would identify asymptomatic subjects with normocalcemic hypoparathyroidism. Methods was defined serum PTH greater than the upper reference range normal albumin-adjusted calcium, excluding common secondary causes (renal failure [estimated glomerular filtration rate Results In 2364 men from MrOS, we 9 (prevalence 0.4%) 26 (1.1%). 3450 women DHS, 108 (3.1%) 68 (1.9%). Of hyperparathyroid subjects, 64 had follow-up data. Hypercalcemic developed 1 subject whereas 13 (0.6% of cohort) showed persistently elevated levels normocalcemia. hypoparathyroid data, none overt 2 (0.09%) persistent evidence Conclusions This documents among community-dwelling individuals. Larger studies are needed determine true prevalence natural history these parathyroid disorders.