Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy
作者： Antonia M Fernández-Peralta , Lydia Daimiel , Nargisse Nejda , Daniel Iglesias , Vicente Medina Arana
DOI: 10.1007/S00384-009-0779-Y
关键词: Cancer 、 Allele 、 Colorectal cancer 、 DNA methylation 、 Carcinogenesis 、 Genetics 、 Medicine 、 Epigenetics 、 Cancer research 、 Methylenetetrahydrofolate reductase 、 Genotype
摘要: Background and aims The enzyme MTHFR plays an important role in folate metabolism, is implicated carcinogenesis due to its DNA methylation, repair, synthesis. We analyze the relationship of C677T A1298C polymorphisms with biological, clinicopathological, genetic epigenetic features tumors, patient outcome after treatment 5-FU-based chemotherapy determine contribution genotypes risk colorectal cancer (CRC) response therapy.
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