Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia

摘要: Several recent publications have drawn attention to the role of thyroid hormone status mother on future neuropsychological development child. The screening pregnant women for clinical or subclinical hypothyroidism based second trimester elevated maternal TSH values has been proposed. Here, we summarized present epidemiological and experimental evidence strongly suggesting that conditions resulting in first hypothyroxinemia (a low gestational age circulating free T4, whether not is increased) pose an increased risk poor fetus. This would be a consequence decreased availability T4 developing brain, its only source during trimester; required substrate ontogenically regulated generation T3 amounts needed optimal different brain structures, both temporally spatially. Normal concentrations do not...