A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels.

摘要: Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead in gene expression which important for pathogenesis this tumour. However, assumption has yet be formally tested at a global level. Therefore genome wide analysis copy number and was performed micro-dissected from same NPC biopsies. Cellular suppressor tumour-promoting genes (TSG, TPG) Epstein-Barr Virus (EBV)-encoded oncogenes were examined. The EBV-encoded maintenance protein EBNA1, along with putative LMP1, LMP2 BARF1 expressed majority NPCs analysed. Significant downregulation an average 76 cellular TSGs per found, whilst per-tumour 88 significantly upregulated, TPGs occurred. around 60% both up-and down-regulated different types cancer, suggesting simplistic classification as or may not entirely appropriate concept context-dependent onco-suppressors more extensive than previously recognised. No significant enrichment within regions frequent genomic gain seen but enriched loss. It is suggested loss FHIT driver tumourigenesis. Notwithstanding association loss, on by basis excepting homozygous deletions high-level amplification, there very little correlation between chromosomal aberrations levels NPC.