The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epithelium.

摘要: Phagosomes are converted to phagolysosomes and then residual bodies (also known as lipofuscin granules or age pigment). Lipofuscin of retinal pigment epithelial (RPE) cells single human eyes were isolated analysed for enzyme content fluorescence spectra. The low in lysosomal enzymes they fluoresce yellow-gold. Thin layer chromatography reveals several separable constituents. accumulate with age, the largest increase occurring after first decade life humans. Macular RPE more than non-macular cells.