Resveratrol Inhibits Development of Experimental Endometriosis In Vivo and Reduces Endometrial Stromal Cell Invasiveness In Vitro

摘要: Endometriosis is a common gynecologic disorder characterized by ectopic attachment and growth of endometrial tissues. Resveratrol natural polyphenol with antiproliferative anti-inflammatory properties. Our objective was to study the effects resveratrol on human endometriotic implants in nude mouse model examine its impact stromal (HES) cell invasiveness vitro. Human tissues were obtained from healthy donors. established oophorectomized mice intraperitoneal injection Mice treated 17β-estradiol (8 mg, silastic capsule implants) alone (n = 16) or (6 mg/mouse; n 20) for 10-12 18-20 days beginning 1 day after tissue injection. killed evaluated. A Matrigel invasion assay used HES cells. We assessed number size vivo decreased per 60% (P < 0.001) total volume lesions 80% 0.001). (10-30 μM) also induced concentration-dependent reduction up 78% 0.0001). inhibits development endometriosis reduces These observations may aid novel treatments endometriosis.