Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction
作者： Shawn Choe , Christopher W. Bond , Daniel A. Harrington , Samuel I. Stupp , Kevin T. McVary
DOI: 10.1016/J.NANO.2016.08.032
关键词: Smoothened Receptor 、 Smoothened 、 Materials science 、 Sonic Hedgehog Protein 、 Internal medicine 、 Patched 、 Axoplasmic transport 、 Cell biology 、 Regeneration (biology) 、 Sonic hedgehog 、 Endocrinology 、 PTCH1
摘要: Erectile dysfunction (ED) has high impact on quality of life in prostatectomy, diabetic and aging patients. An underlying mechanism is cavernous nerve (CN) injury, which causes ED up to 80% prostatectomy We examine how sonic hedgehog (SHH) treatment with innovative peptide amphiphile nanofiber hydrogels (PA), promotes CN regeneration after injury. SHH its receptors patched (PTCH1) smoothened (SMO) are localized PG neurons glia. SMO undergoes anterograde transport signal downstream targets. With crush degenerate undergo apoptosis. protein decreases, localization changes the neuronal cell surface, stops. taken at injury site retrograde neurons, allowing occur, remain intact. prevents degeneration, maintains neuronal, glial target signaling, significant as a regenerative therapy.
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sci-hub.se 参考文章(43)
Gabriel D. Dakubo, Shawn T. Beug, Chantal J. Mazerolle, Sherry Thurig, Yaping Wang, Valerie A. Wallace, Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells. Brain Research. ,vol. 1228, pp. 27- 42 ,(2008) , 10.1016/J.BRAINRES.2008.06.058
Eric J. Berns, Shantanu Sur, Liuliu Pan, Joshua E. Goldberger, Sunitha Suresh, Shuming Zhang, John A. Kessler, Samuel I. Stupp, Aligned neurite outgrowth and directed cell migration in self-assembled monodomain gels. Biomaterials. ,vol. 35, pp. 185- 195 ,(2014) , 10.1016/J.BIOMATERIALS.2013.09.077
Frédéric Charron, Elke Stein, Juhee Jeong, Andrew P McMahon, Marc Tessier-Lavigne, The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell. ,vol. 113, pp. 11- 23 ,(2003) , 10.1016/S0092-8674(03)00199-5
Griffin M.F, Malahias M, Hindocha S, Wasim S Khan, Peripheral Nerve Injury: Principles for Repair and Regeneration The Open Orthopaedics Journal. ,vol. 8, pp. 199- 203 ,(2014) , 10.2174/1874325001408010199
X. Navarro, Meritxell Vivó, Antoni Valero-Cabré, Neural plasticity after peripheral nerve injury and regeneration. Progress in Neurobiology. ,vol. 82, pp. 163- 201 ,(2007) , 10.1016/J.PNEUROBIO.2007.06.005
Rafi Heruti, Tzipi Shochat, Dorit Tekes‐Manova, Itshak Ashkenazi, Dan Justo, Prevalence of Erectile Dysfunction Among Young Adults: Results of a Large‐scale Survey The Journal of Sexual Medicine. ,vol. 1, pp. 284- 291 ,(2004) , 10.1111/J.1743-6109.04041.X
Matthias Hammerschmidt, Adam Brook, Andrew P. McMahon, The world according to bedgebog Trends in Genetics. ,vol. 13, pp. 14- 21 ,(1997) , 10.1016/S0168-9525(96)10051-2
HERBERT M. USER, JOHN H. HAIRSTON, DAVID J. ZELNER, KEVIN E. McKENNA, KEVIN T. McVARY, Penile Weight and Cell Subtype Specific Changes in a Post-Radical Prostatectomy Model of Erectile Dysfunction The Journal of Urology. ,vol. 169, pp. 1175- 1179 ,(2003) , 10.1097/01.JU.0000048974.47461.50
Nicholas L. Angeloni, Christopher W. Bond, Yi Tang, Daniel A. Harrington, Shuming Zhang, Samuel I. Stupp, Kevin E. McKenna, Carol A. Podlasek, Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials. ,vol. 32, pp. 1091- 1101 ,(2011) , 10.1016/J.BIOMATERIALS.2010.10.003
Maarten Albersen, Thomas M Fandel, Haiyang Zhang, Lia Banie, Guiting Lin, Dirk De Ridder, Ching-Shwun Lin, Tom F Lue, None, Pentoxifylline Promotes Recovery of Erectile Function in a Rat Model of Postprostatectomy Erectile Dysfunction European Urology. ,vol. 59, pp. 286- 296 ,(2011) , 10.1016/J.EURURO.2010.10.034