Three‑microRNA expression signature predicts survival in triple‑negative breast cancer

摘要: Triple-negative breast cancer (TNBC) is a specific type of with poor overall survival (OS) time. Previous studies revealed that microRNAs (miRNAs/miRs) serve important roles in the pathogenesis, progression and prognosis TNBC. The present study analyzed miRNA expression clinical data patients TNBC downloaded from Cancer Genome Atlas. A total 194 differentially expressed miRNAs were identified between matched normal tissues using cut-off criteria P 2. Of these miRNAs, 65 downregulated 129 upregulated. Using Kaplan-Meier analysis, 77 closely associated OS time (P<0.05). intersection six miRNAs. Log-rank tests based on curves performed two eliminated. prognostic value remaining four was evaluated Cox proportional hazards model multiple logistic regression forward stepwise selection variables. Three (miR-21-3p, miR-659-5p miR-200b-5p) subsequently as independent risk factors model. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analyses target genes three mainly involved 'cell protein metabolism', 'RNA transcriptional regulation', migration', 'MAPK signaling pathway', 'ErbB 'prolactin pathway' 'adherens junctions'. Taken together, results obtained suggested three-miRNA signature may biomarker for