Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection.
作者： James D McCully , Sidney Levitsky
DOI: 10.1016/J.ABB.2003.06.003
关键词: Cell biology 、 Cardioprotection 、 Potassium channel 、 Sarcolemma 、 Chemistry 、 Heart metabolism 、 Cardiac action potential 、 Inner membrane 、 Membrane potential 、 Mitochondrion
摘要: ATP-sensitive potassium channels allow for the coupling of membrane potential to cellular metabolic status. Two K(ATP) channel subtypes coexist in myocardium with one subtype located sarcolemma and other inner mitochondria. The can be pharmacologically modulated by a family structurally diverse agents varied potency selectivity, collectively known as openers blockers. Sufficient evidence exists indicate that particular mitochondrial play an important role both trigger effector surgical cardioprotection. In this review, biochemistry specificity is examined relation
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