Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells
作者： Sharath P. Sasi , Daniel Park , Sujatha Muralidharan , Justin Wage , Albert Kiladjian
DOI: 10.1155/2015/496512
关键词: Cell biology 、 Apoptosis 、 Chemokine 、 Ex vivo 、 Bone marrow 、 Conditioned medium 、 Endothelial stem cell 、 Bioinformatics 、 Medicine 、 In vitro 、 Progenitor cell
摘要: Bone-marrow- (BM-) derived endothelial progenitor cells (EPCs) are critical for cell maintenance and repair. During future space exploration missions astronauts will be exposed to irradiation (IR) composed of a spectrum low-fluence protons (1H) high charge energy (HZE) nuclei (e.g., iron-56Fe) extended time. How the space-type IR affects BM-EPCs is limited. In media transfer experiments in vitro we studied nontargeted effects induced by 1H- 56Fe-IR conditioned medium (CM), which showed significant increase number p-H2AX foci nonirradiated EPCs between 2 24 h. A 2–15-fold levels various cytokines chemokines was observed both types IR-CM at Ex vivo analysis from single, low-dose, full-body mice demonstrated cyclical (early 5–24 h delayed 28 days) apoptosis. This early BM-EPC apoptosis may effect direct exposure, whereas late could result (NTE) that were not traversed directly. Identifying role specific responsible IR-induced NTE inhibiting such prevent long-term loss stem progenitors BM milieu.
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